Regulation of microtubule-based process

Across TCGA patient cohorts, RNA activity of the Regulation of microtubule-based process pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ATAD2_S342, CDK1, and MSH6, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of microtubule-based process activity versus ATAD2_S342 in LUAD (Pearson r = 0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	ATAD2_S342 →	+1.003	+0.027	<.001	<.001	3	7
LUAD	CDK1 →	+0.726	+0.032	<.001	<.001	3	7
LSCC	MSH6 →	+0.489	+0.029	<.001	<.001	3	7
HNSC	RFC2 →	+0.447	+0.064	<.001	<.001	3	6
LUAD	SETDB1_S1066 →	+0.667	+0.031	<.001	<.001	3	6
LSCC	SMARCC2_T322 →	+0.952	+0.039	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032886 vs ATAD2_S342 — LUAD

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