Regulation of establishment or maintenance of cell polarity

Across TCGA patient cohorts, RNA activity of the Regulation of establishment or maintenance of cell polarity pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SHANK3, TNS2, and EPB41L3, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of establishment or maintenance of cell polarity activity versus SHANK3 in GBM (Pearson r = 0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SHANK3 →	+0.361	+0.043	<.001	<.001	3	8
OV	TNS2 →	+0.392	+0.048	.001	.001	3	8
GBM	EPB41L3 →	+0.723	+0.056	<.001	<.001	3	8
BRCA	VWF →	+0.365	+0.033	<.001	<.001	3	8
BRCA	HSPA12B →	+0.503	+0.035	<.001	<.001	3	8
CCRCC	KANK3 →	+0.550	+0.042	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032878 vs SHANK3 — GBM

Explore this scatter interactively →