Regulation of establishment or maintenance of cell polarity

Across TCGA patient cohorts, RNA activity of the Regulation of establishment or maintenance of cell polarity pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLEKHG3, BCL6B, and PCNT, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of establishment or maintenance of cell polarity activity versus PLEKHG3 in LUAD (Pearson r = 0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	PLEKHG3 →	+0.538	+0.717	<.001	.001	3	4
GBM	BCL6B →	-0.393	-0.467	.002	.006	3	4
HNSC	PCNT →	-0.501	-0.361	.001	.008	3	4
CCRCC	STAB1 →	-0.497	-0.899	<.001	<.001	3	3
CCRCC	P3H1 →	-0.306	-0.799	<.001	<.001	3	3
CCRCC	SERPINH1 →	-0.464	-1.258	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032878 vs PLEKHG3 — LUAD

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