Regulation of establishment or maintenance of cell polarity

Across TCGA cell cohorts, RNA activity of the Regulation of establishment or maintenance of cell polarity pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GSN, NACC2, and EIF4B, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of establishment or maintenance of cell polarity activity versus GSN in BONE (Pearson r = 0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	GSN →	+3.288	+0.284	.003	<.001	3	6
SKIN	NACC2 →	+1.421	+0.213	.005	.001	3	6
BONE	EIF4B →	-1.549	-0.312	<.001	<.001	3	5
SKIN	TRPM8 →	+2.546	+0.228	<.001	<.001	3	5
BLOOD_Lymphoma	RHOC →	+2.392	+0.234	.007	.002	3	5
BONE	PPP2R5B →	+1.795	+0.296	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032878 vs GSN — BONE

Explore this scatter interactively →