Cellular response to insulin stimulus

Across TCGA patient cohorts, RNA activity of the Cellular response to insulin stimulus pathway is significantly associated with the RNA expression of multiple genes, with the SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANKRD12, TNKS2, and MED13, each associated with the pathway in up to 34 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to insulin stimulus activity versus ANKRD12 in SCLC (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	ANKRD12 →	+1.605	+0.069	.004	<.001	3	34
UVM	TNKS2 →	+1.602	+0.043	<.001	<.001	3	34
UVM	MED13 →	+1.451	+0.042	<.001	<.001	3	34
UVM	HIPK3 →	+1.538	+0.043	<.001	<.001	3	34
THYM	SASH1 →	+1.873	+0.072	<.001	<.001	3	34
THYM	USP34 →	+1.665	+0.062	<.001	<.001	3	34

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032869 vs ANKRD12 — SCLC

Explore this scatter interactively →