Glomerulus development

Across TCGA patient cohorts, RNA activity of the Glomerulus development pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CYGB, NOLC1_S538, and ASPN, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glomerulus development activity versus CYGB in OV (Pearson r = 0.52).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CYGB →	+0.612	+0.044	<.001	<.001	3	10
OV	NOLC1_S538 →	-0.789	-0.050	.001	<.001	3	10
BRCA	ASPN →	+0.878	+0.051	<.001	<.001	3	9
OV	SERPINF1 →	+0.708	+0.047	<.001	<.001	3	9
OV	SORBS3 →	+0.605	+0.066	<.001	<.001	3	9
UCEC	SYNPO →	+0.537	+0.058	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032835 vs CYGB — OV

Explore this scatter interactively →