Glomerulus development

Across TCGA pan-cancer cohorts, RNA activity of the Glomerulus development pathway is associated with patient survival in 23 of 34 cancer lineages. Pathway activity is summarized from the expression of its 70 member genes.

The strongest signal is observed in uveal melanoma (UVM), where higher Glomerulus development pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as KIRC and LUAD, show the opposite pattern, with higher activity associated with better survival.

UVM, KIRP, and KIRC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	All	0.520	0.860	<.001	87	view →
KIRP	OS	Median	All	0.508	0.814	<.001	70	view →
KIRC	DFS	Quartile	III,IV	0.750	0.496	<.001	65	view →
LGG	OS	Median	All	0.335	0.528	<.001	51	view →
BLCA	OS	Median	II,III,IV	0.545	0.652	.005	39	view →
LUAD	DFS	Median	All	0.735	0.586	.005	38	view →
LIHC	DFS	Quartile	III,IV	0.865	0.290	.002	32	view →
BRCA	DFS	Quartile	III,IV	0.899	0.730	.004	29	view →
STAD	DFS	Median	All	0.479	0.607	.001	27	view →
THCA	DFS	Median	All	0.940	0.862	.001	27	view →
TGCT	DFS	Median	All	0.575	0.784	.009	12	view →
MESO	OS	Tertile	All	0.260	0.445	.012	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

GO:0032835–UVM (DFS)

Open the UVM breakdown →