Glomerulus development

Across TCGA patient cohorts, RNA activity of the Glomerulus development pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GASK1B, CNRIP1, and PMP22, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glomerulus development activity versus GASK1B in OV (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	GASK1B →	+0.743	+0.585	.002	.008	3	6
OV	CNRIP1 →	+0.948	+0.974	<.001	<.001	3	5
OV	PMP22 →	+0.871	+0.717	<.001	<.001	3	5
OV	PDE1B →	+0.740	+0.600	<.001	.005	3	5
OV	AGTR1 →	+0.475	+0.704	<.001	.001	3	5
CCRCC	CLEC1A →	+0.567	+0.642	.003	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032835 vs GASK1B — OV

Explore this scatter interactively →