Glomerulus development

Across TCGA cell cohorts, RNA activity of the Glomerulus development pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LAMC2, LY6E, and HGH1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LAMC2 grouped by Glomerulus development-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	LAMC2 →	-2.516	-1.090	.002	.008	2	5
BREAST	LY6E →	-1.319	-1.006	.004	<.001	3	4
BREAST	HGH1 →	-0.745	-0.762	.009	.006	3	4
LARGE_INTESTINE	ZBTB8A →	+1.013	+0.910	<.001	.001	3	4
LARGE_INTESTINE	TADA1 →	+0.637	+0.879	.003	.006	3	4
BLOOD_Leukemia	SMIM3 →	-1.978	-0.944	.001	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LAMC2 by Glomerulus development activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →