Glomerulus development

Across TCGA cell cohorts, RNA activity of the Glomerulus development pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLEKHA1, BASP1, and SLC12A7, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glomerulus development activity versus PLEKHA1 in BLOOD_Myeloma (Pearson r = -0.71).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	PLEKHA1 →	-1.158	-0.437	.001	.001	3	5
LUNG_NSCLC_LUAD	BASP1 →	+3.194	+0.466	<.001	<.001	3	5
BONE	SLC12A7 →	-3.851	-0.326	<.001	.003	3	4
OVARY	MT1E →	+4.713	+0.493	.009	.001	3	4
OVARY	PLAT →	+3.061	+0.597	<.001	.006	3	4
SOFT_TISSUE	PODXL →	+3.069	+0.801	.005	<.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032835 vs PLEKHA1 — BLOOD_Myeloma

Explore this scatter interactively →