Regulation of natural killer cell differentiation

Across TCGA cell cohorts, RNA activity of the Regulation of natural killer cell differentiation pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYBL2, ZNF768, and PRKCZ, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MYBL2 grouped by Regulation of natural killer cell differentiation-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	MYBL2 →	-0.552	-0.308	.003	.003	3	6
BONE	ZNF768 →	-0.250	-0.343	.002	.005	3	6
UPPER_AERODIGESTIVE_TRACT	PRKCZ →	-0.178	-0.242	.001	.003	3	6
LUNG_NSCLC_LUSC	DDX59 →	+0.263	+0.292	.002	.004	3	5
BREAST	UQCRC2 →	-0.266	-0.177	.004	.001	3	5
LIVER	TLN1 →	+0.538	+1.388	.009	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MYBL2 by Regulation of natural killer cell differentiation activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →