Positive regulation of natural killer cell proliferation

Across TCGA cell cohorts, RNA activity of the Positive regulation of natural killer cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNRF1, PPP1R37, and SMPDL3A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNRF1 grouped by Positive regulation of natural killer cell proliferation-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	ZNRF1 →	-1.253	-0.957	<.001	.001	3	4
BLOOD_Myeloma	PPP1R37 →	-1.663	-1.855	.008	<.001	3	4
LARGE_INTESTINE	SMPDL3A →	-2.083	-1.558	<.001	<.001	3	4
BLOOD_Leukemia	NDST1 →	-1.344	-1.223	.005	.004	3	4
PANCREAS	SURF4 →	-0.787	-1.685	.001	<.001	3	4
BREAST	ELMO3 →	-1.321	-0.950	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNRF1 by Positive regulation of natural killer cell proliferation activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →