Negative regulation of natural killer cell activation

Across TCGA cell cohorts, RNA activity of the Negative regulation of natural killer cell activation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MICA, HLA-B, and HLA-C, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of natural killer cell activation activity versus MICA in LUNG_SCLC (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	MICA →	+3.199	+1.277	<.001	<.001	3	13
SOFT_TISSUE	HLA-B →	+3.918	+0.148	<.001	.001	3	10
LIVER	HLA-C →	+2.743	+0.204	.003	.002	3	10
LIVER	TAP1 →	+3.048	+0.251	<.001	<.001	3	9
LUNG_SCLC	HLA-E →	+3.351	+1.405	<.001	<.001	3	9
LUNG_SCLC	H3-3A →	-0.767	-1.038	.003	.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032815 vs MICA — LUNG_SCLC

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