Regulation of natural killer cell activation

Across TCGA cell cohorts, RNA activity of the Regulation of natural killer cell activation pathway is significantly associated with the shRNA dependency of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLD3, ABI1, and EPDR1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PLD3 grouped by Regulation of natural killer cell activation-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	PLD3 →	-0.362	-0.196	.008	<.001	3	5
CNS	ABI1 →	+0.263	+0.225	.004	<.001	3	5
LUNG_SCLC	EPDR1 →	-0.215	-0.204	.005	<.001	3	4
SOFT_TISSUE	MYBL2 →	-0.426	-0.126	<.001	.002	3	4
SOFT_TISSUE	CRHR2 →	-0.286	-0.203	.006	.009	3	4
BLOOD_Myeloma	CA5A →	+0.237	+0.070	.004	.002	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PLD3 by Regulation of natural killer cell activation activity — BONE

Explore this box plot interactively →