Negative regulation of epinephrine secretion

Across TCGA patient cohorts, RNA activity of the Negative regulation of epinephrine secretion pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC35F2, NAV2, and C2CD4D-AS1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of epinephrine secretion activity versus SLC35F2 in OV (Pearson r = -0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SLC35F2 →	-0.815	-0.522	<.001	.003	3	3
PDAC	NAV2 →	-0.431	-0.486	<.001	.001	3	3
PDAC	C2CD4D-AS1 →	-0.591	-0.550	.004	.001	3	3
GBM	LDHA →	-0.436	-0.604	.003	<.001	3	3
GBM	NRSN1 →	+0.829	+0.777	<.001	<.001	3	3
GBM	NEGR1 →	+0.955	+0.807	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032811 vs SLC35F2 — OV

Explore this scatter interactively →