"Positive regulation of DNA-templated transcription, elongation"

Across TCGA patient cohorts, RNA activity of the "Positive regulation of DNA-templated transcription, elongation" pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NCAPH, BLM, and RFC5, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Positive regulation of DNA-templated transcription, elongation" activity versus NCAPH in UCEC (Pearson r = 0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NCAPH →	+0.933	+0.296	<.001	.004	3	8
UCEC	BLM →	+0.948	+0.404	<.001	<.001	3	8
LSCC	RFC5 →	+0.647	+0.413	<.001	<.001	3	7
UCEC	LMNB1 →	+1.055	+0.302	<.001	.001	3	7
GBM	HELLS →	+1.363	+0.525	<.001	.008	3	7
UCEC	TROAP →	+1.217	+0.267	<.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032786 vs NCAPH — UCEC

Explore this scatter interactively →