Regulation of DNA-templated transcription elongation

Across TCGA cell cohorts, RNA activity of the Regulation of DNA-templated transcription elongation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MVP, PBRM1, and MCM7, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of DNA-templated transcription elongation activity versus MVP in BLOOD_Lymphoma (Pearson r = -0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	MVP →	-3.352	-0.179	<.001	<.001	3	5
BONE	PBRM1 →	+1.509	+0.212	.005	.002	3	5
BLOOD_Lymphoma	MCM7 →	+1.275	+0.178	.004	<.001	3	4
OESOPHAGUS	HMOX2 →	-0.736	-0.108	.009	.003	3	4
BONE	RRM1 →	+1.001	+0.180	.005	.009	3	4
BONE	BAZ1B →	+0.946	+0.236	.005	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032784 vs MVP — BLOOD_Lymphoma

Explore this scatter interactively →