Positive regulation of monooxygenase activity

pathway activity — cross-omics
GO:0032770Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Positive regulation of monooxygenase activity pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PARVG, MNDA, and NR1H3_S198, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
GBMPARVG →+0.628+0.069<.001<.00136
GBMMNDA →+0.867+0.060.001<.00136
BRCANR1H3_S198 →+0.503+0.035<.001.00236
LSCCARRB2 →+0.316+0.056<.001<.00135
LSCCSAMSN1_S107 →+0.698+0.048<.001<.00135
GBMTNFAIP8L2 →+0.635+0.061<.001<.00135
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration