Positive regulation of monooxygenase activity

pathway activity — cross-omics
GO:0032770Cross-omicsPROTEIN-MS → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Positive regulation of monooxygenase activity pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are IGKC_S52, AP1S2_T146, and SZRD1_S37, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
OVIGKC_S52 →+1.622+0.447<.001<.00133
OVAP1S2_T146 →-1.012-0.434<.001<.00133
GBMSZRD1_S37 →-0.420-0.184<.001<.00133
OVACIN1_S490 →+1.175+0.232<.001.00732
LUADSAFB2_T100 →+1.005+0.429<.001<.00132
OVSCMH1 →+0.991+0.178<.001<.00132
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration