Regulation of monooxygenase activity

pathway activity — cross-omics
GO:0032768Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Regulation of monooxygenase activity pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ELAPOR1, ZDHHC11B, and EGFR, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
HNSCELAPOR1 →-1.725-0.447<.001.00133
HNSCZDHHC11B →-0.883-0.349.008.00333
GBMEGFR →+2.375+0.241<.001<.00133
LSCCNOD2 →+0.581+0.148<.001.00433
LSCCNIPAL4 →+0.984+0.189.001.00133
LSCCSFN →+1.218+0.179<.001.00524
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration