Positive regulation of interleukin-6 production

Across TCGA patient cohorts, RNA activity of the Positive regulation of interleukin-6 production pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARHGAP9, FAM78A, and WAS, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of interleukin-6 production activity versus ARHGAP9 in LSCC (Pearson r = 0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ARHGAP9 →	+0.775	+0.421	<.001	<.001	3	7
HNSC	FAM78A →	+0.714	+0.209	<.001	.001	3	7
GBM	WAS →	+0.745	+0.307	<.001	<.001	3	7
GBM	SIRPB2 →	+0.728	+0.190	<.001	.001	3	7
GBM	C5orf58 →	+0.437	+0.343	<.001	<.001	3	7
LSCC	DOCK2 →	+0.619	+0.306	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032755 vs ARHGAP9 — LSCC

Explore this scatter interactively →