Positive regulation of interleukin-17 production

Across TCGA patient cohorts, RNA activity of the Positive regulation of interleukin-17 production pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RCSD1_S351, STK4, and THEMIS2_T593, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of interleukin-17 production activity versus RCSD1_S351 in OV (Pearson r = 0.44).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	RCSD1_S351 →	+0.647	+0.058	.001	<.001	3	10
OV	STK4 →	+0.395	+0.050	.001	.004	3	10
LSCC	THEMIS2_T593 →	+0.799	+0.088	<.001	<.001	3	10
OV	UNC13D →	+0.512	+0.055	<.001	.003	3	10
GBM	WAS →	+0.668	+0.130	<.001	<.001	3	10
UCEC	WIPF1 →	+0.464	+0.092	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032740 vs RCSD1_S351 — OV

Explore this scatter interactively →