Positive regulation of interleukin-17 production

Across TCGA patient cohorts, RNA activity of the Positive regulation of interleukin-17 production pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are WAS, CORO1A, and INPP5D, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of interleukin-17 production activity versus WAS in HNSC (Pearson r = 0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	WAS →	+0.471	+0.848	<.001	<.001	2	8
BRCA	CORO1A →	+0.595	+1.058	<.001	<.001	3	7
GBM	INPP5D →	+0.547	+0.868	<.001	<.001	3	7
GBM	PARVG →	+0.595	+0.852	<.001	<.001	3	7
UCEC	PRKCQ_T538 →	+1.635	+1.309	<.001	<.001	3	7
BRCA	SASH3 →	+0.417	+0.643	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032740 vs WAS — HNSC

Explore this scatter interactively →