Positive regulation of interleukin-17 production

Across TCGA cell cohorts, RNA activity of the Positive regulation of interleukin-17 production pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC7A5, EIF2AK2, and PHC2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of interleukin-17 production activity versus SLC7A5 in PANCREAS (Pearson r = 0.62).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	SLC7A5 →	+2.275	+0.443	.007	.001	2	6
BLOOD_Leukemia	EIF2AK2 →	+0.783	+0.879	.001	<.001	3	4
LIVER	PHC2 →	-1.617	-0.480	.004	.004	3	4
OESOPHAGUS	ZNF594 →	+1.055	+0.227	.008	.008	3	4
LARGE_INTESTINE	ISG15 →	+2.816	+0.397	.001	<.001	3	4
BREAST	A4GALT →	+1.763	+0.242	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032740 vs SLC7A5 — PANCREAS

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