Positive regulation of interleukin-10 production

Across TCGA cell cohorts, RNA activity of the Positive regulation of interleukin-10 production pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARHGAP31, FBXO45, and ELOC, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ARHGAP31 grouped by Positive regulation of interleukin-10 production-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	ARHGAP31 →	-1.680	-0.293	.005	.009	3	4
PANCREAS	FBXO45 →	+0.431	+0.647	.008	.009	3	3
BLOOD_Myeloma	ELOC →	-1.089	-0.342	.008	<.001	3	3
BLOOD_Myeloma	ZNF582 →	-1.041	-0.271	.009	.007	3	3
SOFT_TISSUE	TPST1 →	-0.879	-0.284	.008	.006	3	3
KIDNEY	TWIST1 →	-1.384	-1.139	.006	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ARHGAP31 by Positive regulation of interleukin-10 production activity — SOFT_TISSUE

Explore this box plot interactively →