Negative regulation of interleukin-6 production

Across TCGA cell cohorts, RNA activity of the Negative regulation of interleukin-6 production pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PELP1, CARD16, and APOOL, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PELP1 grouped by Negative regulation of interleukin-6 production-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	PELP1 →	+0.915	+1.224	.003	.008	2	6
SOFT_TISSUE	CARD16 →	-4.566	-1.605	.001	<.001	3	4
SOFT_TISSUE	APOOL →	-0.310	-1.178	.008	<.001	3	4
SOFT_TISSUE	PDE4DIP →	-1.964	-0.975	<.001	.005	3	4
BLOOD_Lymphoma	COG3 →	+0.890	+0.135	.007	<.001	3	4
LUNG_NSCLC_LUAD	PXDC1 →	-1.372	-0.819	.002	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PELP1 by Negative regulation of interleukin-6 production activity — LIVER

Explore this box plot interactively →