Negative regulation of interleukin-5 production

Across TCGA patient cohorts, RNA activity of the Negative regulation of interleukin-5 production pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are WIPF1, ELMO2, and GIMAP4, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of interleukin-5 production activity versus WIPF1 in GBM (Pearson r = 0.58).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	WIPF1 →	+0.381	+0.189	<.001	<.001	3	8
LSCC	ELMO2 →	+0.333	+0.119	<.001	<.001	3	8
GBM	GIMAP4 →	+0.616	+0.154	<.001	<.001	3	8
GBM	LSP1 →	+0.645	+0.143	<.001	<.001	3	8
LSCC	WDR77 →	-0.278	-0.127	<.001	<.001	3	8
GBM	DOCK2 →	+0.653	+0.164	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032714 vs WIPF1 — GBM

Explore this scatter interactively →