Negative regulation of interleukin-4 production

Across TCGA patient cohorts, RNA activity of the Negative regulation of interleukin-4 production pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ARAP1_S229, ZFPM1_S901, and MACIR_S25, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of interleukin-4 production activity versus ARAP1_S229 in HNSC (Pearson r = -0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ARAP1_S229 →	-0.606	-0.516	.001	<.001	3	4
PDAC	ZFPM1_S901 →	+0.635	+0.420	<.001	<.001	3	3
LUAD	MACIR_S25 →	+0.746	+0.782	.007	<.001	3	3
PDAC	PRAG1_S889 →	-0.927	-0.533	<.001	<.001	3	3
HNSC	RELB_S50 →	-1.077	-0.319	<.001	.006	3	3
UCEC	AHNAK_S5318 →	-0.653	-0.317	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032713 vs ARAP1_S229 — HNSC

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