Negative regulation of interleukin-1 production

Across TCGA patient cohorts, RNA activity of the Negative regulation of interleukin-1 production pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DDX17, LCP1, and LCP2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of interleukin-1 production activity versus DDX17 in GBM (Pearson r = -0.54).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	DDX17 →	-0.282	-0.061	<.001	<.001	3	8
GBM	LCP1 →	+0.766	+0.093	<.001	<.001	3	8
GBM	LCP2 →	+0.577	+0.086	<.001	<.001	3	8
GBM	LPXN →	+0.487	+0.056	<.001	<.001	3	8
BRCA	TRIM22 →	+0.548	+0.047	<.001	<.001	3	8
GBM	PSMB10 →	+0.462	+0.083	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032692 vs DDX17 — GBM

Explore this scatter interactively →