Negative regulation of interleukin-1 production

Across TCGA patient cohorts, RNA activity of the Negative regulation of interleukin-1 production pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SHFL, GBP2, and ODF3B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of interleukin-1 production activity versus SHFL in HNSC (Pearson r = 0.18).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SHFL →	+0.345	+0.273	.009	.004	3	5
GBM	GBP2 →	+0.755	+0.160	<.001	<.001	3	5
GBM	ODF3B →	+1.296	+0.273	<.001	<.001	3	5
CCRCC	TTLL12 →	-0.209	-0.401	.004	.001	3	4
GBM	FLRT1 →	-0.938	-0.264	<.001	<.001	3	4
GBM	SNRPD3 →	-0.397	-0.263	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032692 vs SHFL — HNSC

Explore this scatter interactively →