Negative regulation of interleukin-1 alpha production

Across TCGA patient cohorts, RNA activity of the Negative regulation of interleukin-1 alpha production pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are S100A12, S100A8, and ARG1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of interleukin-1 alpha production activity versus S100A12 in GBM (Pearson r = 0.65).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	S100A12 →	+1.359	+0.123	<.001	<.001	3	6
GBM	S100A8 →	+1.101	+0.095	<.001	<.001	3	6
COAD	ARG1 →	+0.783	+0.084	<.001	<.001	3	6
PDAC	PABPN1 →	-0.758	-0.092	.008	.005	3	6
COAD	S100A9 →	+1.090	+0.069	.003	.008	3	5
GBM	SERPINB10 →	+1.112	+0.133	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032690 vs S100A12 — GBM

Explore this scatter interactively →