Negative regulation of type II interferon production

Across TCGA cell cohorts, RNA activity of the Negative regulation of type II interferon production pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EPHA4, FUT11, and CAPS, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EPHA4 grouped by Negative regulation of type II interferon production-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	EPHA4 →	-1.454	-0.842	.004	.004	3	4
LUNG_SCLC	FUT11 →	+1.443	+1.550	<.001	<.001	3	3
STOMACH	CAPS →	-1.881	-1.169	.007	.001	3	3
STOMACH	CDKN2AIPNL →	+0.885	+1.063	<.001	<.001	3	3
STOMACH	GCFC2 →	+0.770	+1.052	<.001	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	SYNGAP1 →	+1.381	+0.219	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EPHA4 by Negative regulation of type II interferon production activity — BREAST

Explore this box plot interactively →