Protein transport into membrane raft

Across TCGA cell cohorts, RNA activity of the Protein transport into membrane raft pathway is significantly associated with the shRNA dependency of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD24, RFTN1, and ZNF451, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CD24 grouped by Protein transport into membrane raft-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	CD24 →	-0.389	-1.254	<.001	.003	1	11
BREAST	RFTN1 →	-0.374	-1.628	<.001	<.001	3	6
SKIN	ZNF451 →	+0.300	+1.308	<.001	.001	3	6
BLOOD_Leukemia	REEP2 →	-0.336	-1.485	.002	.002	3	5
OVARY	RHEBL1 →	-0.263	-1.324	<.001	<.001	3	5
CNS	IL27 →	+0.227	+1.112	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CD24 by Protein transport into membrane raft activity — BONE

Explore this box plot interactively →