Protein transport within lipid bilayer

Across TCGA patient cohorts, RNA activity of the Protein transport within lipid bilayer pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RFTN1, RFTN1_S199, and ZC3H14_S620, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein transport within lipid bilayer activity versus RFTN1 in GBM (Pearson r = 0.26).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RFTN1 →	+0.446	+0.075	.006	.003	3	9
LUAD	RFTN1_S199 →	+0.790	+0.083	<.001	<.001	3	7
LSCC	ZC3H14_S620 →	-0.820	-0.066	<.001	<.001	3	7
PDAC	LRCH3_S415 →	+0.665	+0.043	<.001	<.001	3	7
LSCC	NOL10 →	-0.354	-0.059	<.001	<.001	3	7
LUAD	DNMT1_S714 →	-0.526	-0.056	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032594 vs RFTN1 — GBM

Explore this scatter interactively →