Protein transport within lipid bilayer

Across TCGA pan-cancer cohorts, RNA activity of the Protein transport within lipid bilayer pathway is associated with patient survival in 23 of 34 cancer lineages. Pathway activity is summarized from the expression of its 7 member genes.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher Protein transport within lipid bilayer pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as LUAD and UCS, show the opposite pattern, with higher activity associated with better survival.

LUAD, MESO, and UVM are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	All	0.758	0.625	<.001	74	view →
MESO	OS	Tertile	All	0.443	0.675	.001	65	view →
UVM	OS	Tertile	All	0.773	0.964	<.001	63	view →
UCS	OS	Median	II,III,IV	0.617	0.234	.004	24	view →
LUSC	OS	Median	IV	0.255	0.851	.021	18	view →
COAD	DFS	Median	IV	0.631	0.373	.008	14	view →
SKCM	OS	Median	IV	0.775	0.230	.008	13	view →
CESC	OS	Quartile	All	0.804	0.931	.008	12	view →
READ	DFS	Quartile	III,IV	0.229	0.784	.005	12	view →
KIRP	DFS	Quartile	III,IV	0.300	0.792	.008	11	view →
ACC	DFS	Quartile	IV	0.082	0.668	.010	11	view →
GBM	DFS	Median	All	0.199	0.300	.011	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

GO:0032594–LUAD (OS)

Open the LUAD breakdown →