Protein transport within lipid bilayer

Across TCGA cell cohorts, RNA activity of the Protein transport within lipid bilayer pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FOXO1, PDK3, and ZNF436, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein transport within lipid bilayer activity versus FOXO1 in OVARY (Pearson r = 0.82).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	FOXO1 →	+1.953	+1.518	.002	.001	3	4
KIDNEY	PDK3 →	+1.341	+1.400	<.001	<.001	2	4
URINARY_TRACT	ZNF436 →	+1.436	+1.378	.004	<.001	3	3
URINARY_TRACT	DMAC1 →	-1.256	-1.378	.001	<.001	3	3
URINARY_TRACT	ETV6 →	+1.076	+1.378	.005	<.001	3	3
URINARY_TRACT	RETREG3 →	+0.905	+1.477	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032594 vs FOXO1 — OVARY

Explore this scatter interactively →