Response to vitamin K

Across TCGA cell cohorts, RNA activity of the Response to vitamin K pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FHOD3, GAMT, and ETNK2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FHOD3 grouped by Response to vitamin K-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	FHOD3 →	-1.351	-0.879	.002	.007	3	4
LARGE_INTESTINE	GAMT →	+3.108	+0.634	.002	<.001	3	4
LARGE_INTESTINE	ETNK2 →	+1.478	+0.743	<.001	.007	3	4
BONE	ADARB1 →	+0.929	+0.891	<.001	.001	3	4
BREAST	CSAD →	+1.557	+0.795	.002	.004	3	4
LUNG_SCLC	DPY30 →	+0.941	+0.582	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FHOD3 by Response to vitamin K activity — CNS

Explore this box plot interactively →