Mitochondrial translation

Across TCGA patient cohorts, RNA activity of the Mitochondrial translation pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PRCC, INTS3, and INTS8, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitochondrial translation activity versus PRCC in LSCC (Pearson r = 0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PRCC →	+0.264	+0.038	<.001	<.001	3	6
LSCC	INTS3 →	+0.209	+0.034	<.001	<.001	3	6
LSCC	INTS8 →	+0.183	+0.041	<.001	<.001	3	6
LSCC	NOP16 →	+0.313	+0.040	<.001	<.001	3	6
PDAC	SND1_S645 →	-0.389	-0.024	.001	<.001	3	5
LSCC	GTF3C4 →	+0.404	+0.054	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032543 vs PRCC — LSCC

Explore this scatter interactively →