Mitochondrial translation

Across TCGA patient cohorts, RNA activity of the Mitochondrial translation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PDE1B, FSTL1, and MT-CO2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitochondrial translation activity versus PDE1B in BRCA (Pearson r = -0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PDE1B →	-0.539	-0.315	<.001	<.001	3	8
OV	FSTL1 →	-1.229	-0.325	<.001	<.001	3	7
PDAC	MT-CO2 →	+0.761	+0.298	<.001	<.001	3	7
COAD	MT-CO1 →	+0.670	+0.278	.001	<.001	3	7
OV	CXCL12 →	-1.523	-0.283	.002	.003	3	7
UCEC	ZEB2 →	-0.657	-0.233	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032543 vs PDE1B — BRCA

Explore this scatter interactively →