Mitochondrial translation

Across TCGA cell cohorts, RNA activity of the Mitochondrial translation pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NUTM2D, C2, and NPIPB4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NUTM2D grouped by Mitochondrial translation-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	NUTM2D →	+0.652	+0.261	.002	.001	3	4
PANCREAS	C2 →	+0.541	+0.380	.002	<.001	3	4
BREAST	NPIPB4 →	+1.599	+0.419	<.001	<.001	3	4
URINARY_TRACT	ANKRD13D →	-1.674	-0.475	.003	<.001	3	4
OVARY	PFKL →	+0.669	+0.245	.003	.005	3	3
OESOPHAGUS	MOB3B →	+1.508	+0.554	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NUTM2D by Mitochondrial translation activity — OVARY

Explore this box plot interactively →