Microvillus organization

Across TCGA patient cohorts, RNA activity of the Microvillus organization pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SSB, RSU1, and SNRPD2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Microvillus organization activity versus SSB in GBM (Pearson r = -0.11).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SSB →	-0.261	-0.053	<.001	<.001	3	7
GBM	RSU1 →	+0.349	+0.056	<.001	<.001	3	6
GBM	SNRPD2 →	-0.368	-0.062	<.001	<.001	3	6
PDAC	TLN1_S2040 →	+0.561	+0.067	<.001	<.001	3	6
GBM	TNS3_S811 →	+0.516	+0.055	.004	.001	3	6
GBM	WDR12 →	-0.506	-0.066	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032528 vs SSB — GBM

Explore this scatter interactively →