Negative regulation of phosphoprotein phosphatase activity

pathway activity — cross-omics
GO:0032515Cross-omicsPROTEIN-MS → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Negative regulation of phosphoprotein phosphatase activity pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ROCK2_S1374, USP24_S1285, and TBC1D5_S460, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
PDACROCK2_S1374 →+0.993+0.183<.001<.00135
LUADUSP24_S1285 →+0.584+0.131<.001<.00135
CCRCCTBC1D5_S460 →+0.443+0.257<.001<.00134
CCRCCEPS8L2_S197 →+0.809+0.244<.001<.00134
CCRCCPPP3CC_S483 →+0.561+0.216<.001<.00134
PDACRERE_S679 →-0.591-0.193<.001<.00134
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration