Late endosome to vacuole transport via multivesicular body sorting pathway

Across TCGA patient cohorts, RNA activity of the Late endosome to vacuole transport via multivesicular body sorting pathway pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPL10A, RPS2, and SEC23B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Late endosome to vacuole transport via multivesicular body sorting pathway activity versus RPL10A in PDAC (Pearson r = -0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	RPL10A →	-0.203	-0.033	.001	.006	3	5
PDAC	RPS2 →	-0.183	-0.033	<.001	<.001	3	5
LUAD	SEC23B →	-0.278	-0.046	<.001	<.001	3	5
LUAD	PDIA4 →	-0.314	-0.036	.002	.004	3	5
LUAD	RPS16 →	-0.128	-0.027	.008	.006	3	5
OV	EPRS1 →	-0.304	-0.051	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032511 vs RPL10A — PDAC

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