Endosome to lysosome transport via multivesicular body sorting pathway

Across TCGA patient cohorts, RNA activity of the Endosome to lysosome transport via multivesicular body sorting pathway pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPS16, RPS2, and UCK1_S253, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endosome to lysosome transport via multivesicular body sorting pathway activity versus RPS16 in LUAD (Pearson r = -0.26).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RPS16 →	-0.124	-0.027	.001	.003	3	5
LUAD	RPS2 →	-0.173	-0.034	.002	.007	3	5
OV	UCK1_S253 →	+0.589	+0.046	<.001	<.001	3	5
BRCA	RPL30 →	-0.163	-0.039	.005	.001	1	6
PDAC	RPL38 →	-0.380	-0.039	.003	.002	3	4
LUAD	RPS18 →	-0.299	-0.034	.003	.005	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032510 vs RPS16 — LUAD

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