Endosome to lysosome transport via multivesicular body sorting pathway

Across TCGA pan-cancer cohorts, RNA activity of the Endosome to lysosome transport via multivesicular body sorting pathway pathway is associated with patient survival in 18 of 34 cancer lineages. Pathway activity is summarized from the expression of its 17 member genes.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher Endosome to lysosome transport via multivesicular body sorting pathway pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as HNSC and KIRC, show the opposite pattern, with higher activity associated with better survival.

HNSC, LIHC, and KIRC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Quartile	III,IV	0.852	0.668	<.001	83	view →
LIHC	OS	Quartile	II,III,IV	0.341	0.729	<.001	26	view →
KIRC	DFS	Median	All	0.859	0.735	.004	26	view →
KIRP	DFS	Tertile	All	0.593	0.793	.001	21	view →
PAAD	DFS	Median	All	0.362	0.560	.005	13	view →
SARC	DFS	Tertile	All	0.682	0.521	.013	12	view →
LUAD	DFS	Quartile	IV	0.415	0.877	.045	6	view →
UCEC	DFS	Quartile	All	0.802	0.889	.032	6	view →
ESCA	OS	Median	III,IV	0.544	0.317	.012	6	view →
ACC	OS	Median	IV	0.344	0.724	.038	6	view →
GBM	OS	Quartile	All	0.191	0.440	.017	3	view →
THYM	DFS	Tertile	All	1.000	0.746	.037	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

GO:0032510–HNSC (OS)

Open the HNSC breakdown →