Endosome to lysosome transport via multivesicular body sorting pathway

Across TCGA patient cohorts, RNA activity of the Endosome to lysosome transport via multivesicular body sorting pathway pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AP4E1, CLDN16, and POLR2K, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endosome to lysosome transport via multivesicular body sorting pathway activity versus AP4E1 in UCEC (Pearson r = -0.22).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	AP4E1 →	-0.212	-0.176	.005	.002	3	4
BRCA	CLDN16 →	-0.238	-0.126	.008	.006	3	4
UCEC	POLR2K →	-0.426	-0.176	.002	.008	3	3
LSCC	PXDNL →	+0.259	+0.169	.004	.001	3	3
OV	ERICH6B →	-0.108	-0.158	<.001	<.001	3	3
OV	CMTM4 →	-0.435	-0.146	.007	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032510 vs AP4E1 — UCEC

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