Endosome to lysosome transport via multivesicular body sorting pathway

Across TCGA cell cohorts, RNA activity of the Endosome to lysosome transport via multivesicular body sorting pathway pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GFUS, IRF5, and FAM117B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GFUS grouped by Endosome to lysosome transport via multivesicular body sorting pathway-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	GFUS →	+0.753	+0.281	.001	.001	3	4
BLOOD_Leukemia	IRF5 →	+2.049	+0.191	.002	<.001	3	4
BLOOD_Leukemia	FAM117B →	-0.917	-0.224	.001	.002	3	4
URINARY_TRACT	NAP1L1 →	-1.028	-0.263	<.001	.003	3	4
OESOPHAGUS	RHOF →	+2.345	+0.228	.005	.004	2	4
OESOPHAGUS	ZNF219 →	-1.214	-0.229	.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GFUS by Endosome to lysosome transport via multivesicular body sorting pathway activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →