Endosome to lysosome transport via multivesicular body sorting pathway

Across TCGA cell cohorts, RNA activity of the Endosome to lysosome transport via multivesicular body sorting pathway pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF24, CBX7, and RPRD1A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endosome to lysosome transport via multivesicular body sorting pathway activity versus ZNF24 in LUNG_SCLC (Pearson r = 0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ZNF24 →	+0.891	+0.241	.001	.001	3	5
LUNG_SCLC	CBX7 →	-1.013	-0.242	.001	<.001	3	4
LUNG_SCLC	RPRD1A →	+0.572	+0.187	.005	.002	3	4
BLOOD_Myeloma	PLAAT4 →	-3.406	-0.255	.002	.007	3	4
BLOOD_Lymphoma	MCOLN2 →	+1.791	+0.149	.002	.007	3	4
STOMACH	DNAJC30 →	+0.636	+0.312	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032510 vs ZNF24 — LUNG_SCLC

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