Cytokinetic process

Across TCGA patient cohorts, RNA activity of the Cytokinetic process pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TOP2A_S1377, UCHL1, and TACC3_S71, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cytokinetic process activity versus TOP2A_S1377 in LUAD (Pearson r = 0.65).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TOP2A_S1377 →	+1.018	+0.079	<.001	<.001	3	8
LSCC	UCHL1 →	+0.853	+0.039	.005	.001	3	7
LUAD	TACC3_S71 →	+1.182	+0.072	<.001	<.001	3	7
OV	PLOD2 →	+0.763	+0.048	.005	.001	3	7
LUAD	TOP2A →	+1.030	+0.092	<.001	<.001	3	7
CCRCC	ANLN_S485 →	+1.328	+0.068	.001	.006	2	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032506 vs TOP2A_S1377 — LUAD

Explore this scatter interactively →