Cytokinetic process

Across TCGA cell cohorts, RNA activity of the Cytokinetic process pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MPDU1, TPRA1, and SAV1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MPDU1 grouped by Cytokinetic process-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	MPDU1 →	-0.782	-0.201	<.001	<.001	3	5
OVARY	TPRA1 →	+0.777	+0.208	.007	.007	3	5
PANCREAS	SAV1 →	+1.066	+0.217	.002	.004	3	5
PANCREAS	GIPC1 →	+1.281	+0.355	<.001	<.001	3	4
OVARY	POP5 →	-0.532	-0.201	.009	.004	3	4
OVARY	CD47 →	+1.608	+0.258	.005	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MPDU1 by Cytokinetic process activity — OVARY

Explore this box plot interactively →